靶点、药物与关联证据查询：参数与补充说明

用法和示例见功能教程。

各功能按作用、API、输入、输出、示例代码和结果说明介绍。运行前按说明准备凭据、本地文件与可选依赖；远程结果随数据库版本与查询时间变化。

按药物名称或编号查询作用机制

dnakit.databases.ch_embl_get_drug_mechanisms(*, limit=None, offset=None, drug_chembl_id=None, drug_name=None, molecule_chembl_id=None, chembl_id=None, drug_chembl_id__exact=None, verbose=True)

参数	类型	必填 / 默认值	说明与约束
limit	integer	None	当前请求的返回数量上限；不是全库命中总数。
offset	integer	None	分页起始偏移；对应当前查询结果。
drug_chembl_id	string	None	ChEMBL drug/molecule ID (e.g., "CHEMBL1201580" for adalimumab, "CHEMBL4535757" for sotorasib).
drug_name	string	None	Drug name for automatic ChEMBL ID lookup (e.g., "trastuzumab", "lapatinib", "aspirin"). Case-insensitive. Triggers internal ChEMBL molecule search — use drug_chembl_id if you already know the ID.
molecule_chembl_id	string	None	Alias for drug_chembl_id. ChEMBL molecule ID (e.g., "CHEMBL25" for aspirin).
chembl_id	string	None	Alias for drug_chembl_id. ChEMBL ID (e.g., "CHEMBL3301622").
drug_chembl_id__exact	string	None	DNAKit optional alias for drug_chembl_id
verbose	bool	True	运行提示开关。

查询 ChEMBL 分子结构与性质

dnakit.databases.ch_embl_get_molecule(*, chembl_id=None, format=None, molecule_chembl_id=None, verbose=True)

参数	类型	必填 / 默认值	说明与约束
chembl_id	string	None	ChEMBL molecule ID, e.g., 'CHEMBL25'
format	string	None	Response format
molecule_chembl_id	string	None	Alias for chembl_id. ChEMBL molecule ID, e.g., CHEMBL1229517.
verbose	bool	True	运行提示开关。

查询靶点相关的生物活性测量值

dnakit.databases.ch_embl_get_target_activities(*, target_chembl_id__exact=None, limit=None, offset=None, target_chembl_id=None, chembl_id=None, verbose=True)

参数	类型	必填 / 默认值	说明与约束
target_chembl_id__exact	string	None	ChEMBL target ID (e.g., 'CHEMBL2074'). To find a target ID, use ChEMBL_search_targets with a target name or gene symbol.
limit	integer	None	当前请求的返回数量上限；不是全库命中总数。
offset	integer	None	分页起始偏移；对应当前查询结果。
target_chembl_id	string	None	Alias for target_chembl_id__exact. ChEMBL target ID (e.g., CHEMBL213).
chembl_id	string	None	DNAKit optional alias for target_chembl_id
verbose	bool	True	运行提示开关。

以下参数组必须且只能提供一组：target_chembl_id__exact; target_chembl_id。

按名称与研发阶段检索药物

dnakit.databases.ch_embl_search_drugs(*, query=None, max_phase=None, limit=None, offset=None, molecule_chembl_id=None, q=None, verbose=True)

参数	类型	必填 / 默认值	说明与约束
query	string	None	Drug name to search for (partial match, case-insensitive). E.g., "sotorasib", "olaparib", "imatinib".
max_phase	integer	None	Filter by maximum development phase (0-4)
limit	integer	None	当前请求的返回数量上限；不是全库命中总数。
offset	integer	None	分页起始偏移；对应当前查询结果。
molecule_chembl_id	string	None	Filter by ChEMBL molecule ID (e.g., "CHEMBL1201580" for adalimumab).
q	string	None	DNAKit optional alias for query
verbose	bool	True	运行提示开关。

按名称、物种或类型检索药物靶点

dnakit.databases.ch_embl_search_targets(*, target_chembl_id=None, pref_name__contains=None, organism=None, target_type=None, fields=None, limit=None, offset=None, q=None, verbose=True)

参数	类型	必填 / 默认值	说明与约束
target_chembl_id	string	None	Filter by target ChEMBL ID
pref_name__contains	string	None	Filter by target name (contains)
organism	string	None	Filter by organism (e.g., 'Homo sapiens')
target_type	string	None	Filter by target type (e.g., 'SINGLE PROTEIN', 'PROTEIN COMPLEX')
fields	array	None	Optional list of ChEMBL target fields to include in each returned target object (projection). ToolUniverse maps this to ChEMBL's only query parameter (comma-separated). Supported fields: target_chembl_id, pref_name, organism, target_type, target_components. {"uniqueItems": true, "items": {"type": "string", "enum": ["target_chembl_id", "pref_name", "organism", "target_type", "target_components"]}}
limit	integer	None	当前请求的返回数量上限；不是全库命中总数。
offset	integer	None	分页起始偏移；对应当前查询结果。
q	string	None	DNAKit optional alias for pref_name__contains
verbose	bool	True	运行提示开关。

查看已不可用的 CTD 化学物基因互作查询

dnakit.databases.ctd_get_chemical_gene_interactions(*, input_terms, verbose=True)

参数	类型	必填 / 默认值	说明与约束
input_terms	string	必填	Chemical name, CAS RN, or MeSH ID. Unused -- this tool always returns an error; see the tool description.
verbose	bool	True	运行提示开关。

批量查询药物与基因互作证据

dnakit.databases.dgidb_get_drug_gene_interactions(*, genes=None, gene_name=None, gene=None, interaction_sources=None, interaction_types=None, verbose=True)

参数	类型	必填 / 默认值	说明与约束
genes	array	None	List of gene symbols (e.g., ['EGFR', 'BRAF']). Also accepts a single gene as string. Aliases: gene_name, gene. {"items": {"type": "string"}}
gene_name	string	None	Alias for genes. Single gene symbol (e.g., 'EGFR').
gene	string	None	Alias for genes. Single gene symbol (e.g., 'EGFR').
interaction_sources	array	None	Optional filter by data sources (e.g., ['DrugBank', 'ChEMBL']). {"items": {"type": "string"}}
interaction_types	array	None	Optional filter by interaction types (e.g., ['inhibitor', 'antagonist']). {"items": {"type": "string"}}
verbose	bool	True	运行提示开关。

查询基因的可成药类别

dnakit.databases.dgidb_get_gene_druggability(*, genes=None, gene_name=None, gene=None, verbose=True)

参数	类型	必填 / 默认值	说明与约束
genes	array	None	List of gene symbols to check druggability. Aliases: gene_name, gene. {"items": {"type": "string"}}
gene_name	string	None	Alias for genes. Single gene symbol (e.g., 'EGFR').
gene	string	None	Alias for genes. Single gene symbol (e.g., 'EGFR').
verbose	bool	True	运行提示开关。

查询药物基本信息与批准状态

dnakit.databases.drugbank_get_drug_basic_info_by_drug_name_or_id(*, query, case_sensitive=None, exact_match=None, limit=None, verbose=True)

参数	类型	必填 / 默认值	说明与约束
query	string	必填	Drug name or DrugBank ID to search for
case_sensitive	boolean	None	Select True to perform a case-sensitive search
exact_match	boolean	None	Select True to require an exact match with the queried name or ID
limit	integer	None	Maximum number of results to return
verbose	bool	True	运行提示开关。

查询药效学、作用机制与药代动力学

dnakit.databases.drugbank_get_pharmacology_by_drug_name_or_drugbank_id(*, query, case_sensitive=None, exact_match=None, limit=None, verbose=True)

参数	类型	必填 / 默认值	说明与约束
query	string	必填	Drug name or Drugbank ID to search for
case_sensitive	boolean	None	Select True to perform a case-sensitive search
exact_match	boolean	None	Select True to require an exact match
limit	integer	None	Maximum number of results to return
verbose	bool	True	运行提示开关。

查询药物靶点、酶、载体与转运体

dnakit.databases.drugbank_get_targets_by_drug_name_or_drugbank_id(*, query, case_sensitive=None, exact_match=None, limit=None, verbose=True)

参数	类型	必填 / 默认值	说明与约束
query	string	必填	Drug name or Drugbank ID to search for
case_sensitive	boolean	None	Select True to perform a case-sensitive search
exact_match	boolean	None	Select True to require an exact match
limit	integer	None	Maximum number of results to return
verbose	bool	True	运行提示开关。

按名称与同义词检索 DrugBank 词表

dnakit.databases.drugbank_vocab_search(*, query, search_fields=None, case_sensitive=None, exact_match=None, limit=None, verbose=True)

参数	类型	必填 / 默认值	说明与约束
query	string	必填	Search query string. Can be drug name, synonym, DrugBank ID, or any text to search for.
search_fields	array	None	Fields to search in. Available fields: 'DrugBank ID', 'Accession Numbers', 'Common name', 'CAS', 'UNII', 'Synonyms', 'Standard InChI Key'. Defaults to ['Common name', 'Synonyms', 'DrugBank ID']. {"items": {"type": "string"}}
case_sensitive	boolean	None	Whether the search should be case sensitive.
exact_match	boolean	None	Whether to perform exact matching instead of substring matching.
limit	integer	None	Maximum number of results to return.
verbose	bool	True	运行提示开关。

查询文献支持的疾病靶点关联评分

dnakit.databases.europepmc_disease_target_score(*, efoId, pageSize=None, verbose=True)

参数	类型	必填 / 默认值	说明与约束
efoId	string	必填	The EFO (Experimental Factor Ontology) ID of the disease, e.g., 'MONDO_0011996' for chronic myelogenous leukemia
pageSize	integer	None	Upstream fetch batch size (max 100), NOT a limit on results returned. The tool pages through all of the disease's associated targets regardless of this value -- 'pageSize': 10 on MONDO_0005011 (Crohn disease) still returns 390 scored targets. Lower it only to make each upstream request smaller.
verbose	bool	True	运行提示开关。

查询表达数据支持的疾病靶点关联评分

dnakit.databases.expression_atlas_disease_target_score(*, efoId, pageSize=None, verbose=True)

参数	类型	必填 / 默认值	说明与约束
efoId	string	必填	The EFO (Experimental Factor Ontology) ID of the disease, e.g., 'MONDO_0011996' for chronic myelogenous leukemia
pageSize	integer	None	Number of results per page (default: 100, max: 100)
verbose	bool	True	运行提示开关。

查询药品有效成分

dnakit.databases.fda_get_active_ingredient_info_by_drug_name(*, drug_name, limit=None, skip=None, verbose=True)

参数	类型	必填 / 默认值	说明与约束
drug_name	string	必填	The name of the drug.
limit	integer	None	The number of records to return.
skip	integer	None	The number of records to skip.
verbose	bool	True	运行提示开关。

查询药品标签中的不良反应信息

dnakit.databases.fda_get_adverse_reactions_by_drug_name(*, drug_name, limit=None, skip=None, verbose=True)

参数	类型	必填 / 默认值	说明与约束
drug_name	string	必填	The name of the drug.
limit	integer	None	The number of records to return.
skip	integer	None	The number of records to skip.
verbose	bool	True	运行提示开关。

查询药品黑框警告与相关安全信息

dnakit.databases.fda_get_boxed_warning_info_by_drug_name(*, drug_name, limit=None, skip=None, verbose=True)

参数	类型	必填 / 默认值	说明与约束
drug_name	string	必填	The name of the drug.
limit	integer	None	The number of records to return.
skip	integer	None	The number of records to skip.
verbose	bool	True	运行提示开关。

查询药品标签中的临床研究信息

dnakit.databases.fda_get_clinical_studies_info_by_drug_name(*, drug_name, limit=None, skip=None, verbose=True)

参数	类型	必填 / 默认值	说明与约束
drug_name	string	必填	The name of the drug.
limit	integer	None	The number of records to return.
skip	integer	None	The number of records to skip.
verbose	bool	True	运行提示开关。

查询药品适应证与使用说明

dnakit.databases.fda_get_indications_by_drug_name(*, drug_name, limit=None, skip=None, verbose=True)

参数	类型	必填 / 默认值	说明与约束
drug_name	string	必填	The name of the drug.
limit	integer	None	The number of records to return.
skip	integer	None	The number of records to skip.
verbose	bool	True	运行提示开关。

查询药品标签中的作用机制

dnakit.databases.fda_get_mechanism_of_action_by_drug_name(*, drug_name, limit=None, skip=None, verbose=True)

参数	类型	必填 / 默认值	说明与约束
drug_name	string	必填	The name of the drug.
limit	integer	None	The number of records to return.
skip	integer	None	The number of records to skip.
verbose	bool	True	运行提示开关。

查询代谢物的疾病关联

dnakit.databases.hmdb_get_diseases(*, operation=None, hmdb_id=None, compound_name=None, pubchem_cid=None, limit=None, verbose=True)

参数	类型	必填 / 默认值	说明与约束
operation	string	None	提供方操作模式；默认值与允许值见本行约束。
hmdb_id	string	None	HMDB ID (e.g., HMDB0000122)
compound_name	string	None	Compound name (e.g., glucose)
pubchem_cid	string	None	PubChem CID as an alternative identifier to hmdb_id or compound_name.
limit	integer	None	Maximum number of disease associations to return (default 50).
verbose	bool	True	运行提示开关。

按编号或名称查询代谢物信息

dnakit.databases.hmdb_get_metabolite(*, operation=None, hmdb_id=None, compound_name=None, verbose=True)

参数	类型	必填 / 默认值	说明与约束
operation	string	None	提供方操作模式；默认值与允许值见本行约束。
hmdb_id	string	None	HMDB ID (e.g., HMDB0000122)
compound_name	string	None	Compound name (e.g., glucose)
verbose	bool	True	运行提示开关。

按名称或分子式检索代谢物

dnakit.databases.hmdb_search(*, operation=None, query, verbose=True)

参数	类型	必填 / 默认值	说明与约束
operation	string	None	提供方操作模式；默认值与允许值见本行约束。
query	string	必填	Compound name or molecular formula to search
verbose	bool	True	运行提示开关。

按疾病查询已知相关药物

dnakit.databases.open_targets_get_associated_drugs_by_disease_efo_id(*, efoId, size=None, verbose=True)

参数	类型	必填 / 默认值	说明与约束
efoId	string	必填	The EFO ID of the disease.
size	integer	None	当前返回页的数量上限；不自动遍历后续页。
verbose	bool	True	运行提示开关。

按靶点查询相关药物与研发阶段

dnakit.databases.open_targets_get_associated_drugs_by_target_ensembl_id(*, ensemblId, size=None, verbose=True)

参数	类型	必填 / 默认值	说明与约束
ensemblId	string	必填	The Ensembl ID of the target.
size	integer	None	当前返回页的数量上限；不自动遍历后续页。
verbose	bool	True	运行提示开关。

查询疾病相关的 HPO 表型

dnakit.databases.open_targets_get_associated_phenotypes_by_disease_efo_id(*, efoId, verbose=True)

参数	类型	必填 / 默认值	说明与约束
efoId	string	必填	The efoId of a disease or phenotype.
verbose	bool	True	运行提示开关。

分页查询疾病关联靶点

dnakit.databases.open_targets_get_associated_targets_by_disease_efo_id(*, efoId, size=None, index=None, verbose=True)

参数	类型	必填 / 默认值	说明与约束
efoId	string	必填	The efoId of a disease or phenotype.
size	integer	None	Number of top-scored associated targets to return (default 50). A disease can have thousands of associated targets; raise this to retrieve more than the first page.
index	integer	None	Zero-based page index for paginating beyond the first size targets (default 0).
verbose	bool	True	运行提示开关。

查询 GWAS 可信集合与位点基因映射

dnakit.databases.open_targets_get_credible_set_detail(*, studyLocusId, verbose=True)

参数	类型	必填 / 默认值	说明与约束
studyLocusId	string	必填	Credible set identifier (studyLocusId), a 32-character hash (e.g., 'b758d8fb10924f5338cbad8d27c7dee8'). Obtain from variant credible sets or study credible sets queries.
verbose	bool	True	运行提示开关。

查询疾病本体的父级与祖先概念

dnakit.databases.open_targets_get_disease_ancestors_parents_by_efo_id(*, efoId, verbose=True)

参数	类型	必填 / 默认值	说明与约束
efoId	string	必填	The EFO ID of the disease.
verbose	bool	True	运行提示开关。

查询疾病本体的子级与后代概念

dnakit.databases.open_targets_get_disease_descendants_children_by_efo_id(*, efoId, verbose=True)

参数	类型	必填 / 默认值	说明与约束
efoId	string	必填	The EFO ID of the disease.
verbose	bool	True	运行提示开关。

查询疾病名称、描述与跨库引用

dnakit.databases.open_targets_get_disease_description_by_efo_id(*, efoId, verbose=True)

参数	类型	必填 / 默认值	说明与约束
efoId	string	必填	The EFO ID of the disease.
verbose	bool	True	运行提示开关。

按疾病名称解析本体编号与描述

dnakit.databases.open_targets_get_disease_id_description_by_name(*, diseaseName=None, query=None, verbose=True)

参数	类型	必填 / 默认值	说明与约束
diseaseName	string	None	The name of the disease to search for.
query	string	None	DNAKit optional alias for diseaseName
verbose	bool	True	运行提示开关。

查询疾病同义名称

dnakit.databases.open_targets_get_disease_synonyms_by_efo_id(*, efoId, verbose=True)

参数	类型	必填 / 默认值	说明与约束
efoId	string	必填	The EFO ID of the disease.
verbose	bool	True	运行提示开关。

查询疾病所属的治疗领域

dnakit.databases.open_targets_get_disease_therapeutic_areas_by_efo_id(*, efoId, verbose=True)

参数	类型	必填 / 默认值	说明与约束
efoId	string	必填	The EFO ID of the disease.
verbose	bool	True	运行提示开关。

分页查询靶点关联疾病与表型

dnakit.databases.open_targets_get_diseases_phenotypes_by_target_ensembl(*, ensemblId, page=None, verbose=True)

参数	类型	必填 / 默认值	说明与约束
ensemblId	string	必填	The ensemblId of a target.
page	object	None	Pagination parameters. count in the response is the total across all pages; omit this to get the first page only. {"properties": {"index": {"type": "integer", "description": "The index of the page to retrieve (0-based)."}, "size": {"type": "integer", "description": "The number of associations per page."}}}
verbose	bool	True	运行提示开关。

查询药物显著不良事件记录

dnakit.databases.open_targets_get_drug_adverse_events_by_chembl_id(*, chemblId, page=None, verbose=True)

参数	类型	必填 / 默认值	说明与约束
chemblId	string	必填	The ChEMBL ID of the drug.
page	object	None	Pagination settings. {"properties": {"index": {"type": "integer", "description": "Index of the page to fetch, starting from 0."}, "size": {"type": "integer", "description": "Number of entries per page."}}}
verbose	bool	True	运行提示开关。

按通用名称解析药物 ChEMBL 编号

dnakit.databases.open_targets_get_drug_chemb_id_by_generic_name(*, drugName=None, query=None, verbose=True)

参数	类型	必填 / 默认值	说明与约束
drugName	string	None	The generic name of the drug for which the ID is required.
query	string	None	DNAKit optional alias for drugName
verbose	bool	True	运行提示开关。

按 ChEMBL 编号查询药物适应证

dnakit.databases.open_targets_get_drug_indications_by_chembl_id(*, chemblId, verbose=True)

参数	类型	必填 / 默认值	说明与约束
chemblId	string	必填	The chemblId of the drug for which to retrieve treatable phenotypes information.
verbose	bool	True	运行提示开关。

按 ChEMBL 编号查询药物作用机制

dnakit.databases.open_targets_get_drug_mechanisms_of_action_by_chembl_id(*, chemblId, verbose=True)

参数	类型	必填 / 默认值	说明与约束
chemblId	string	必填	The ChEMBL ID of the drug.
verbose	bool	True	运行提示开关。

按 ChEMBL 编号查询药物警告

dnakit.databases.open_targets_get_drug_warnings_by_chembl_id(*, chemblId, verbose=True)

参数	类型	必填 / 默认值	说明与约束
chemblId	string	必填	The ChEMBL ID of the drug.
verbose	bool	True	运行提示开关。

按证据来源筛选靶点疾病关联

dnakit.databases.open_targets_get_evidence_by_datasource(*, efoId=None, ensemblId=None, gene_symbol=None, disease_name=None, datasourceIds=None, size=None, verbose=True)

参数	类型	必填 / 默认值	说明与约束
efoId	string	None	Disease EFO/MONDO ID (e.g., 'MONDO_0005011' for Crohn disease). Alternative to disease_name.
ensemblId	string	None	Target Ensembl gene ID (e.g., 'ENSG00000141510' for TP53). Alternative to gene_symbol.
gene_symbol	string	None	HGNC gene symbol (e.g., 'TP53', 'BRCA1'). Auto-resolved to ensemblId.
disease_name	string	None	Disease or phenotype name (e.g., 'Crohn disease'). Auto-resolved to efoId.
datasourceIds	array	None	List of datasource IDs to filter evidence. Examples: ['gwas_credible_sets', 'europepmc'], ['eva', 'clinical_precedence'], ['intogen', 'cancer_gene_census']. For genetic (GWAS) association evidence use 'gwas_credible_sets' — the retired 'ot_genetics_portal' name is remapped automatically. Omit or pass empty array for all sources. {"items": {"type": "string"}}
size	integer	None	Maximum evidence rows to return (default: 50)
verbose	bool	True	运行提示开关。

查询 GWAS 研究队列与统计元数据

dnakit.databases.open_targets_get_gwas_study(*, studyId, verbose=True)

参数	类型	必填 / 默认值	说明与约束
studyId	string	必填	GWAS study accession ID (e.g., 'GCST000392' for T1D Barrett et al., 'GCST90029024' for T2D Loh et al.)
verbose	bool	True	运行提示开关。

查询靶点相关文献记录

dnakit.databases.open_targets_get_publications_by_target_ensembl_id(*, entityId, additionalIds=None, startYear=None, startMonth=None, endYear=None, endMonth=None, verbose=True)

参数	类型	必填 / 默认值	说明与约束
entityId	string	必填	The ID of the entity (ensemblID).
additionalIds	array	None	List of additional IDs to include in the search. {"items": {"type": "string"}}
startYear	integer	None	Year at the lower end of the filter.
startMonth	integer	None	Month at the lower end of the filter.
endYear	integer	None	Year at the higher end of the filter.
endMonth	integer	None	Month at the higher end of the filter.
verbose	bool	True	运行提示开关。

查询与疾病相似的生物医学实体

dnakit.databases.open_targets_get_similar_entities_by_disease_efo_id(*, efoId, threshold, size, verbose=True)

参数	类型	必填 / 默认值	说明与约束
efoId	string	必填	The EFO ID of the disease.
threshold	number	必填	Threshold similarity between 0 and 1. Only results above threshold are returned.
size	integer	必填	Number of similar entities to fetch.
verbose	bool	True	运行提示开关。

查询指定 GWAS 研究的可信集合

dnakit.databases.open_targets_get_study_credible_sets(*, studyIds, size=None, index=None, verbose=True)

参数	类型	必填 / 默认值	说明与约束
studyIds	array	必填	GWAS study accession IDs (e.g., ['GCST000392']) {"items": {"type": "string"}}
size	integer	None	Number of credible sets to return (default 20)
index	integer	None	Page index for pagination (0-based, default 0)
verbose	bool	True	运行提示开关。

查询靶点的功能类别

dnakit.databases.open_targets_get_target_classes_by_ensembl_id(*, ensemblId, verbose=True)

参数	类型	必填 / 默认值	说明与约束
ensemblId	string	必填	The Ensembl ID of the target.
verbose	bool	True	运行提示开关。

查询靶点的 GO 功能注释

dnakit.databases.open_targets_get_target_gene_ontology_by_ensembl_id(*, ensemblId, verbose=True)

参数	类型	必填 / 默认值	说明与约束
ensemblId	string	必填	The Ensembl ID of the target for which to retrieve Gene Ontology annotations.
verbose	bool	True	运行提示开关。

查询靶点的基因组位置与方向

dnakit.databases.open_targets_get_target_genomic_location_by_ensembl_id(*, ensemblId, verbose=True)

参数	类型	必填 / 默认值	说明与约束
ensemblId	string	必填	The Ensembl ID of the target for which to retrieve genomic location information.
verbose	bool	True	运行提示开关。

查询靶点的同源基因

dnakit.databases.open_targets_get_target_homologues_by_ensembl_id(*, ensemblId, verbose=True)

参数	类型	必填 / 默认值	说明与约束
ensemblId	string	必填	The Ensembl ID of the target for which to retrieve homologues.
verbose	bool	True	运行提示开关。

按名称解析靶点标识与描述

dnakit.databases.open_targets_get_target_id_description_by_name(*, targetName, verbose=True)

参数	类型	必填 / 默认值	说明与约束
targetName	string	必填	The name of the target for which the ID is required.
verbose	bool	True	运行提示开关。

分页查询靶点互作伙伴与证据

dnakit.databases.open_targets_get_target_interactions_by_ensembl_id(*, ensemblId, page=None, verbose=True)

参数	类型	必填 / 默认值	说明与约束
ensemblId	string	必填	The Ensembl ID of the target.
page	object	None	Pagination parameters. {"properties": {"index": {"type": "integer", "description": "The index of the page to retrieve."}, "size": {"type": "integer", "description": "The number of items per page."}}}
verbose	bool	True	运行提示开关。

查询靶点已知安全性风险记录

dnakit.databases.open_targets_get_target_safety_profile_by_ensembl_id(*, ensemblId, verbose=True)

参数	类型	必填 / 默认值	说明与约束
ensemblId	string	必填	The Ensembl ID of the target for which to retrieve safety liabilities.
verbose	bool	True	运行提示开关。

查询靶点对不同治疗方式的可开发性

dnakit.databases.open_targets_get_target_tractability_by_ensembl_id(*, ensemblId, verbose=True)

参数	类型	必填 / 默认值	说明与约束
ensemblId	string	必填	The Ensembl ID of the target.
verbose	bool	True	运行提示开关。

查询包含指定变异的 GWAS 可信集合

dnakit.databases.open_targets_get_variant_credible_sets(*, variantId=None, size=None, variant_id=None, verbose=True)

参数	类型	必填 / 默认值	说明与约束
variantId	string	None	Open Targets variant ID in format chr_position_ref_alt (e.g., '10_112998590_C_T' for rs7903146)
size	integer	None	Number of credible sets to return (default 10)
variant_id	string	None	DNAKit optional alias for variantId
verbose	bool	True	运行提示开关。

查询变异坐标、频率与功能后果

dnakit.databases.open_targets_get_variant_info(*, variantId, verbose=True)

参数	类型	必填 / 默认值	说明与约束
variantId	string	必填	Open Targets variant ID in format chr_position_ref_alt (e.g., '10_112998590_C_T' for rs7903146, '19_44908684_T_C' for rs429358). Use the search tool to find variant IDs from rsIDs.
verbose	bool	True	运行提示开关。

转换疾病与表型的跨数据库标识

dnakit.databases.open_targets_map_any_disease_id_to_all_other_ids(*, inputId, verbose=True)

参数	类型	必填 / 默认值	说明与约束
inputId	string	必填	Any known disease ID (e.g. OMIM:604302, UMLS:C0003873, ICD10:M05, MONDO_0008383, etc.)
verbose	bool	True	运行提示开关。

联合检索疾病、靶点与药物实体

dnakit.databases.open_targets_multi_entity_search_by_query_string(*, queryString, entityNames=None, page=None, verbose=True)

参数	类型	必填 / 默认值	说明与约束
queryString	string	必填	The search string for querying information.
entityNames	array	None	List of entity names to search for (e.g., target, disease, drug). {"items": {"type": "string"}}
page	object	None	Pagination settings with index and size. {"properties": {"index": {"type": "integer", "description": "Pagination index."}, "size": {"type": "integer", "description": "Pagination size."}}}
verbose	bool	True	运行提示开关。

按疾病或性状查找 GWAS 研究

dnakit.databases.open_targets_search_gwas_studies_by_disease(*, diseaseIds=None, enableIndirect=None, disease_name=None, disease=None, trait=None, size=None, verbose=True)

参数	类型	必填 / 默认值	说明与约束
diseaseIds	array	None	Disease ontology IDs (e.g., ['MONDO_0005148'] for type 2 diabetes, ['MONDO_0004975'] for Alzheimer disease) {"items": {"type": "string"}}
enableIndirect	boolean	None	Include studies for child disease terms (default true)
disease_name	string	None	Disease or trait name for auto-resolution (e.g., 'type 2 diabetes'). Resolved to diseaseIds automatically.
disease	string	None	Alias for disease_name.
trait	string	None	Alias for disease_name.
size	integer	None	当前返回页的数量上限；不自动遍历后续页。
verbose	bool	True	运行提示开关。

查询 IntOGen 肿瘤驱动基因关联证据

dnakit.databases.open_targets_target_disease_evidence(*, efoId=None, ensemblId=None, gene_symbol=None, disease_name=None, verbose=True)

参数	类型	必填 / 默认值	说明与约束
efoId	string	None	EFO/MONDO disease ID (e.g., MONDO_0005011). Alternative to disease_name.
ensemblId	string	None	Ensembl gene ID (e.g., ENSG00000141510). Alternative to gene_symbol.
gene_symbol	string	None	HGNC gene symbol (e.g., 'TP53', 'BRCA1'). Auto-resolved to ensemblId.
disease_name	string	None	Disease or phenotype name (e.g., 'Crohn disease', 'breast carcinoma'). Auto-resolved to efoId.
verbose	bool	True	运行提示开关。

将化合物名称解析为 PubChem CID

dnakit.databases.pub_chem_get_cid_by_compound_name(*, name=None, compound_name=None, verbose=True)

参数	类型	必填 / 默认值	说明与约束
name	string	None	Chemical compound name (e.g., "Aspirin", "Acetaminophen") or IUPAC name. Do not use disease names or medical conditions.
compound_name	string	None	Alias for name. The compound name to look up.
verbose	bool	True	运行提示开关。

按 CID 查询化合物分子性质

dnakit.databases.pub_chem_get_compound_properties_by_cid(*, cid, properties=None, verbose=True)

参数	类型	必填 / 默认值	说明与约束
cid	integer	必填	PubChem compound ID to query, e.g., 2244 (Aspirin).
properties	array | string | null	None	Optional list of PubChem property names to retrieve (e.g. ['MolecularFormula','InChIKey','XLogP','IUPACName','MolecularWeight']). If omitted, returns a default set (MolecularWeight, IUPACName, ConnectivitySMILES). For SMILES use the current names 'ConnectivitySMILES' (was 'CanonicalSMILES') or 'SMILES' (was 'IsomericSMILES') — a legacy name still returns data, but under the current key, not the one requested. See PubChem PUG-REST property tables for valid names. Accepts a list or a comma-separated string. {"items": {"type": "string"}}
verbose	bool	True	运行提示开关。

查询通路支持的疾病靶点关联评分

dnakit.databases.reactome_disease_target_score(*, efoId, pageSize=None, verbose=True)

参数	类型	必填 / 默认值	说明与约束
efoId	string	必填	The EFO (Experimental Factor Ontology) ID of the disease, e.g., 'MONDO_0011996' for chronic myelogenous leukemia
pageSize	integer	None	Number of results per page (default: 100, max: 100)
verbose	bool	True	运行提示开关。